The demise of Nemesio Rubén Oseguera Cervantes, infamous as El Mencho and the leader of the Jalisco New Generation Cartel (CJNG), occurred during a coordinated operation that involved the United States. This event has ignited a series of violent retaliations across various regions of Mexico, particularly concentrated in the state of Jalisco where the cartel is based. Following his death, CJNG members have resorted to blocking roads and damaging government properties as acts of vengeance, which has raised alarm among local and federal authorities regarding public safety in these areas.

The governor of Jalisco, Pablo Lemus Navarro, has advised residents and travelers to avoid using highways due to the escalation of violence, noting that the unrest has spread to at least five other federal entities. Reports indicate that in various locations within Jalisco, cartel members have set vehicles ablaze and created obstacles on roadways to obstruct law enforcement actions. This chaos has prompted immediate reactions from multiple layers of government as they assess the implications for public safety and security protocols in light of the CJNG's aggressive tactics.

In response to the unfolding situation, the United States government issued a security alert for American citizens present in Jalisco. This measure reflects not only the immediate concerns for the safety of U.S. nationals but also underscores the broader implications of drug cartel-related violence in Mexico, which remains a significant issue both domestically and for neighboring countries. The ongoing instability raises questions about the effectiveness of strategies for combating organized crime and protecting civilian populations in regions entrenched in cartel influence.