Darío Lopérfido, a significant figure in Argentine culture, has died at the age of 61 after a struggle with Amyotrophic Lateral Sclerosis (ALS), a degenerative neuromuscular disease diagnosed in July 2024. His career included notable roles such as the Secretary of Culture and Media of Argentina during Fernando de la Rúa's presidency and Minister of Culture of Buenos Aires under Horacio Rodríguez Larreta. His passing has been met with condolences from various sectors of the cultural community who recognized his contributions to the arts.

In his final interview with LA NACION, Lopérfido discussed the profound impact of his illness on his life and work. He described ALS as 'uncomfortable,' outlining the personal challenges it brought, particularly regarding his limitations in fulfilling his professional roles. His candid reflections provided insight into how he navigated this difficult journey, revealing a poignant relationship with the concept of death and his legacy in the cultural sector.

Lopérfido's death marks a significant loss for Argentine culture, as he played an influential role in various artistic initiatives, notably during his tenure at the Teatro Colón. His influence extended beyond directorships, as he was a vocal advocate for the arts and the importance of culture at a national level. This highlights the ongoing discourse around health care, cultural investment, and the personal battles many face behind public personas, particularly in the arts community.