Darío Lopérfido, who served as Secretary of Culture during Fernando de la Rúa's presidency in Argentina, has died at 61 in Madrid. He had been suffering from amyotrophic lateral sclerosis (ALS), a neurodegenerative disease, for over a year before his passing. Lopérfido was a prominent figure in Argentine culture, having held significant roles including the artistic director of the Teatro Colón and various cultural leadership positions in Buenos Aires under different administrations.

Throughout his career, Lopérfido was involved in several high-profile cultural initiatives and was known for his commitment to the arts. He also served as the president of Ópera Latinoamérica and was a recognized voice in the political landscape surrounding culture and media in Argentina. His work in promoting Latin American opera and supporting artists positioned him as a central figure in the cultural dialogue of the region.

In 2025, Lopérfido produced a series of interviews that highlighted both cultural and political figures, including those facing similar health challenges, thus intertwining his personal experiences with broader societal issues. His death not only marks the loss of an influential cultural leader but also serves as a reminder of the challenges faced by individuals living with debilitating illnesses like ALS, highlighting the importance of continued dialogue and support in these areas.