A special epigenetic shield protects the brains of super-elders from memory loss
Recent research indicates that the brains of 'super-elders' produce new neurons more effectively than their peers, potentially offering new perspectives on combating dementia.
A recent study conducted by American researchers has discovered that the brains of individuals classified as 'super-elders'—elderly people exhibiting exceptional memory capabilities—generate new nerve cells more effectively than their contemporaries. This observation may contribute significant insights into strategies for fighting dementia in the long term. The findings counter a long-standing belief that human brains no longer produce new neurons after childhood, suggesting that there might be possibilities for regeneration as people age.
Traditionally, as people age, there is a decline in cognitive function due to the accumulation of errors in brain cells that can lead to memory disorders and eventually cell death. This knowledge, critical since the early 20th century, seemed to indicate that cognitive decline was inevitable. However, this study and advancements in research over the last few decades challenge this notion and may provide pathways toward understanding age-related memory loss in humans.
Previous experiments carried out on mice and monkeys contradicted the idea of a static brain in the animal kingdom more broadly, but conclusive evidence for humans has remained elusive due to limitations in research technologies. With advancements in techniques that specifically analyze brain tissues, researchers hope to gain a clearer understanding of the mechanisms that contribute to the resilience seen in super-elders, potentially inspiring new therapies aimed at dementia prevention and treatment.