Menopause marks a significant period in a woman's life, often accompanied by a multitude of physical and psychological symptoms that can severely impact daily living. This hormonal transition is linked to cognitive issues, including deficits in memory, attention, and language, leading to heightened challenges in both personal and professional spheres. The study highlights these cognitive concerns, emphasizing the need for greater awareness and understanding of how menopause affects mental health.

To alleviate menopause symptoms such as hot flashes, depressive symptoms, and sleep disorders, many women turn to hormone replacement therapy (HRT). In the UK, it is estimated that 15% of women are prescribed HRT for menopause-related symptoms, with usage rates higher in Europe, reaching 18% in Spain and as much as 55% in France. This disparity in HRT use raises questions about the accessibility and communication of menopause-related health resources across different cultures.

Despite the prevalence of menopause and its effects, there remains limited understanding about its impact on brain health and cognition, as well as the implications of HRT usage. This study, which analyzed data from nearly 125,000 women, aims to fill this gap by providing insights into how these hormonal changes influence cognitive function and overall mental well-being, with the potential for informing future health strategies for women during this transitional phase of life.