Menopause is a critical phase in a woman's life, often characterized by a range of debilitating physical and psychological symptoms that can significantly impact daily living. Among these are cognitive issues such as memory deficits, attention problems, and language difficulties. Many women seek relief from these symptoms through hormone replacement therapy (HRT), but the proportion of those receiving prescriptions varies significantly between countries, with estimates around 15% in England and up to 55% in France.

Recent research aimed to clarify the relationship between menopause, cognitive function, and mental health by analyzing data from nearly 125,000 women in the UK Biobank, a substantial health and genetic database. The study categorized participants into three groups: pre-menopausal, peri-menopausal, and post-menopausal, focusing on how each stage influences brain health and cognitive abilities. As the understanding of menopause's aspects remain limited, the research addresses essential gaps in knowledge regarding the effects of HRT and the menopausal transition on women's brain function.

The implications of this study are far-reaching, as it not only sheds light on the mental and cognitive challenges faced by women during menopause but also opens the door for further investigations into therapeutic options. Understanding these effects is crucial for improving quality of life for women experiencing menopause and ensuring appropriate medical support and interventions that can mitigate cognitive decline and promote mental well-being.