In Ntungamo District, Uganda, a rapidly spreading outbreak of Foot and Mouth Disease (FMD) is causing significant disruptions to livestock markets and revenue collection. This outbreak reportedly started in the Nyakyera Sub-county due to the influx of animals from unknown sources and has been persistent for nearly two months. In response, local authorities have stepped in, suspending cattle markets and imposing quarantine measures throughout the district to contain the spread of the disease. In reaction to the rising crisis, district officials led by Dr. Yake Basulira, the district veterinary officer, have implemented emergency containment measures. These steps followed the confirmation of the disease, with FMD task teams being organized to manage the situation and protect both livestock and local economies. Despite these efforts, tensions have emerged between veterinary authorities and farmers, particularly concerning the resistance to vaccination programs aimed at controlling the outbreak. The situation calls for urgent attention as the effects of the outbreak strain the local economy and challenge public health initiatives. The ongoing resistance from farmers complicates efforts to mitigate the disease's impact and underscores the need for effective communication and collaboration between authorities and the farming community to foster compliance and ultimately safeguard livestock health.