On March 21, a series of devastating drone strikes carried out by Russian forces on Dnipropetrovsk Oblast led to the deaths of two individuals and injured five more, including a child. The Head of the Dnipropetrovsk Oblast Military Administration, Oleksandr Hanzha, reported that there were over 30 attacks across two districts, particularly affecting the Synelnykove and Nikopol districts. The intense bombardment caused significant destruction, as vehicles caught fire and residential areas suffered damage.

In the Synelnykove district, the targeted attacks hit the Mykolaivka and Vasylkivka hromadas, where the casualties occurred. Emergency services responded to the scene to control the fires and assist the victims. Witnesses reported hearing continuous explosions throughout the day as drones were deployed, indicating a coordinated assault on civilian infrastructure.

Moreover, in the Nikopol district, various hromadas including Nikopol, Pokrovske, Marhanets, Myrove, and Chervonohryhorivka were hit, leading to extensive infrastructural damage, which included destruction of homes and commercial properties. The ongoing conflict in the region has raised local tensions, with civilians bearing the brunt of these military operations, prompting urgent calls for international attention and support for those affected by the war.