In a disappointing match in Seville, Panathinaikos faced a tough defeat against Real Betis, losing 4-0 and subsequently being eliminated from the Europa League. The game began on a grim note for Panathinaikos, with Betis taking the lead early at the 8th minute through Ruibal, who capitalized on a close-range chance following a shot that ricocheted off the post. Despite a significant opportunity for Panathinaikos to score first, their efforts were thwarted by Betis's goalkeeper, Pau López.

Betis displayed a dominant performance in the first half, especially until the 30th minute, when Panathinaikos started to find its footing. Just as it seemed the first half would conclude at 1-0, Amrabat struck a long-range shot during stoppage time, taking advantage of a defensive miscue from Panathinaikos's Lafonte to double Betis's lead to 2-0. With their confidence soaring, Betis came out strong in the second half, extending their lead to 3-0 in the 53rd minute when Kusco scored from a well-executed team play.

The situation worsened for Panathinaikos, who visibly crumbled under the pressure, conceding a fourth goal in the 66th minute from Anthony. This emphatic defeat signifies not only a disappointing end to Panathinaikos's European ambitions this season but also raises questions about the team's future performance in domestic and international competitions. The loss reflects the challenges faced by the team in competing against stronger European sides.