Amy Schumer recently recounted her negative experience with the weight-loss medication Ozempic, which gained popularity for its effects but has also been criticized for adverse reactions. During an interview on Howard Stern's radio show in 2025, Schumer described how, after taking the drug three years prior, she faced severe side effects that left her bedridden. She noted that she experienced vomiting and a lack of energy, stating that she couldn’t even lift her head off the pillow, ultimately making it impossible for her to maintain a normal life.

Despite losing over 14 kilos (about 30 pounds) quickly, the severity of the side effects forced Schumer to stop using Ozempic. The growing concerns regarding the drug are underlined by Schumer’s testimony, which adds to the myriad reports about the challenges faced by individuals who take it. The news reflects a broader conversation around the use of medications for weight loss, as many people openly discuss their struggles and adverse effects, revealing that the drug may not be suitable for everyone, especially those prone to gastrointestinal issues.

Additionally, experts, including a report from La Vanguardia, suggest that genetic factors may play a role in individual reactions to Ozempic. Schumer is noted to carry a gene associated with nausea, GDF15, which could explain her severe response to the drug. As the dialogue about safe weight loss methods continues, Schumer's story highlights the importance of personal testimonials in evaluating the effectiveness and safety of such treatments, urging potential users to consider their individual health contexts before starting medications like Ozempic.