The Central Headquarters of the Seal of the Prophets serves as the highest authority for military operations within the Iranian armed forces, facilitating coordination between various branches, particularly between the regular army and the Islamic Revolutionary Guard Corps (IRGC). This command has gained prominence following a joint military attack by the United States and Israel in February 2026, which targeted civilian, security, and military sites in Iran, resulting in the assassination of key Iranian figures including Supreme Leader Ali Khamenei.

In the aftermath of the attack, the Central Headquarters issued official statements and comments regarding Iran's response and defensive operations, characterizing the event as a "brutal assault on its security and sovereignty." This indicates the significant role the headquarters plays not just in military strategy, but also in shaping Iran's narrative regarding external threats, as it represents the apex of military coordination and decision-making in the country.

Given its high-level authority, the commander of the Central Headquarters is appointed by the Supreme Leader, further emphasizing its integral position within Iran's military hierarchy. The headquarters signifies Iran's military readiness and operational capabilities, highlighting the country's ongoing struggle against perceived external aggressions, and showcasing the political significance of military leadership in the shaping of national defense policies.