At least 22 fatalities were reported in violent pro-Iran protests that erupted in Pakistan and Iraq, in response to strikes that resulted in the death of Iran's supreme leader, Ayatollah Ali Khamenei. In Karachi, demonstrators gathered outside the US consulate, where tensions escalated as some protesters attempted to breach the consulate's premises while others set fires, leading to a deadly encounter with security forces that resulted in at least ten deaths and numerous injuries. Videos showed protesters chanting in defiance, indicating widespread anger over the perceived aggression against Iran.

In addition to the unrest in Karachi, protests in Gilgit-Baltistan and Islamabad also turned deadly, contributing to the rising death toll. Eyewitness accounts described chaotic scenes as protesters expressed their outrage over US-Israeli actions, symbolically linking their grievances to the US presence in the region. The situation intensified as demonstrators clashed with security forces, leading to the deployment of live ammunition and tear gas to disperse the crowds, further fueling violence and public unrest.

In Iraq, the protests mirrored those in Pakistan as security forces responded with tear gas to prevent protesters from storming the US embassy in Baghdad. The use of force against demonstrators reflects a broader trend of escalating regional tensions following the death of Khamenei, indicating a significant risk of further unrest. The implications of these protests are substantial, as they not only highlight the deep-seated grievances related to US foreign policy in the Middle East but also raise questions about the stability of the region amidst increasing violence and retaliation from pro-Iran factions.