The draw for the Champions League Round of 16 will take place in Nyon today, establishing key matchups between La Liga's top clubs and the Premier League. Atlético de Madrid is guaranteed to face an English team, while Real Madrid and FC Barcelona each have a 50% chance of being pitted against a Premier League club. The potential adversaries for these Spanish teams include prominent clubs such as Liverpool, Manchester City, Tottenham, and Newcastle, underlining the competition's high stakes.