On the 22nd, Nemesio Oseguera, the head of Jalisco New Generation Cartel (CJNG), was killed during a military operation that was initiated by tracking his lover's whereabouts. Defense Minister Ricardo Treviño revealed in a press conference that the operation began with the Mexican military following Oseguera's lover and associates. They located Oseguera hiding in a shack on the outskirts of Tapalpa, Jalisco, and executed a raid shortly after the lover left. During the confrontation, Oseguera's security guards opened fire on the military, resulting in a firefight where El Mencho and two of his bodyguards were injured and later died during transport to a hospital in Mexico City.

The New York Times reported that the CIA played a crucial role in the operation by providing important intelligence to the Mexican authorities. Officials have refrained from disclosing details about the sources of this information but emphasized that the CIA has a range of intelligence collection methods, including informant networks, aerial surveillance, and communication intercepts. This collaboration underscores the complex relationship between U.S. intelligence and Mexican security forces in the ongoing battle against drug trafficking and organized crime.

In the aftermath of Oseguera's death, violent uprisings orchestrated by cartel members resulted in the deaths of 25 national guard soldiers, alongside 34 armed assailants and at least one civilian, bringing the total death toll to a minimum of 62. The chaos led to widespread concerns regarding security in Jalisco, especially as the region is set to host significant events like the 2026 North American World Cup. As the Mexican government works to regain control and restore normalcy following this violent upheaval, questions remain about their ability to dismantle such powerful organizations and prevent further violence during critical times ahead.