Eric Dane, the acclaimed actor known for portraying Mark Sloan on the hit medical drama 'Grey's Anatomy', has died at 53, according to a family statement. He had been battling amyotrophic lateral sclerosis (ALS) since April 2025 and spent his final days surrounded by friends, his devoted wife, and their two daughters, who were central to his life. The family described him as a loving individual who was cherished by many.

Dane had previously revealed his ALS diagnosis while still working on his role in HBO's 'Euphoria'. His journey with the disease led him to become a passionate advocate for awareness and research regarding ALS, aspiring to make a difference for others facing similar struggles. His dedication to the cause was highlighted in the family’s statement, emphasizing the impact he made not only as an actor but also as a humanitarian in his final years.

In addition to 'Grey's Anatomy', Dane was well-known for his role as Cal Jacobs in 'Euphoria' and as Tom Chandler in 'The Last Ship', marking a significant part of his career post-'Grey's Anatomy'. His contributions to the entertainment industry and his advocacy work will be remembered fondly by fans and colleagues alike, as he leaves behind a remarkable legacy both onscreen and off.