In a tragic incident in Karachi, Pakistan, at least 16 individuals lost their lives, and several others were injured following an explosion of a gas cylinder in a residential building. Local rescue officials reported that this occurred while families were preparing for Suhoor during the month of Ramadan, creating a sense of urgency and panic in the densely populated area. The building, which was three stories high, collapsed due to what officials described as 'unknown' causes, with the explosion resonating around 4 AM local time. The regional ambulance spokesperson, Hassan Khan, confirmed the casualty numbers, expressing concern over the presence of women and children among the deceased. While a municipal official suggested that the explosion was likely due to gas, an investigation is underway to ascertain the exact circumstances surrounding this tragic event. Authorities are focusing on the safety regulations related to gas cylinders as they begin their inquiry. President Asif Ali Zardari expressed deep condolences to the victims' families and ordered that the injured receive the best possible medical care. He also urged the Sindh provincial government to promptly conduct rescue operations and enforce construction regulations to prevent future tragedies like this. Such incidents unfortunately highlight ongoing concerns regarding building safety and gas regulation enforcement in Pakistan, necessitating systemic reforms to ensure public safety.