Feb 15 • 12:31 UTC 🇦🇷 Argentina Clarin (ES)

Genetic inheritance explains nearly 50% of life expectancy

A new study suggests that genetic inheritance may account for almost half of the variation in human longevity, challenging previous beliefs that life expectancy is primarily influenced by environmental factors.

For many decades, it was commonly believed that life expectancy was mainly determined by environmental factors, lifestyle choices, and randomness. However, a new study presents a counterargument, isolating biological aging from deaths caused by external factors, hence revealing that genetic inheritance contributes significantly, accounting for approximately 50% of the variability in human longevity. This finding retests prior assumptions and underscores the importance of genetics in determining lifespan.

Ben Shenhar, a systems biology expert and the lead author of the study, emphasizes that many of us know someone who has lived into their 90s or even 100s despite lifestyle choices that may not be healthy, such as smoking or poor diet. Interestingly, about 30% of centenarians reach this age without significant health issues. Shenhar points out that it's not just about looks; the genetic makeup of these individuals seems to offer protective mechanisms against the typical deterioration associated with aging.

The study raises crucial questions about the extent to which our lifespan is influenced by inherited traits. With the historical focus on extrinsic mortality factors, such as accidents and diseases, this research steers the conversation towards understanding the intrinsic genetic factors that play a vital role in prolonging life. This shift in focus could have significant implications for public health policies and personal health strategies as people become more aware of the interplay between genetics and lifestyle in promoting longevity.

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